Job Title: Scientist, Preformulation
📍 Location: Cambridge, MA
📄 Contract Length: 6 months
Job Summary:
We are seeking an exceptional candidate to contribute to preformulation research in a small, fast-paced, and highly collaborative team. This contract position is within the Formulation Sciences group of Technical Operations, supporting pre-clinical development.
The candidate will work full-time onsite and be responsible for executing laboratory activities related to the transition of novel small molecule compounds from Discovery into Development. The role directly supports pre-clinical and clinical programs.
An ideal candidate will have a strong foundation in analytical techniques such as UPLC/HPLC (Empower proficiency) and an understanding of early drug development processes and experiments . Experience in preformulation development and physicochemical characterization is highly desirable but not required.
Ideal Experience: 0-3 years in pharmaceutical sciences (preformulation, analytical, or formulation development).
Key Responsibilities:
✔️ Prepare buffers and common lab solutions
✔️ Execute analytical experiments using XRPD, DSC, TGA, DVS, optical microscopy, and UPLC/HPLC (Empower)
✔️ Screen excipients/formulation vehicles for solubility and stability to optimize preclinical formulations for non-GLP and GLP preclinical studies
✔️ Perform drug substance and formulation stability studies to ensure optimal formulation design
✔️ Coordinate vehicle/formulation preparations for in vivo studies
✔️ Maintain an accurate, timely, and compliant laboratory notebook
Qualifications:
🎓 Education: BS degree in chemistry, analytical chemistry, pharmaceutics, chemical engineering, or material sciences
🧪 Experience in the Discovery and Development interface (desirable but not required)
⚗️ Hands-on experience with common excipients and volumetric glassware
🖥️ Proficiency with UPLC/HPLC and Empower Software
🔬 Knowledge of and interest in small molecule and pre-clinical formulation development
Capabilities & Skills:
✅ Ability to prioritize and manage multiple tasks
✅ Self-motivated with a willingness to learn and seek assistance when needed
✅ Comfortable in a results-driven, highly accountable environment
✅ Strong team player and collaborator , with effective communication skills
Preferred Technical Skills:
🔹 Laboratory Equipment & Techniques
🔹 Pharmaceutical Formulation
🔹 Thermal Analysis (DSC, TGA, DVS)
🔹 Analytical Chemistry
🔹 Waters HPLC & Empower Software
🔹 Polarized Light Microscopy
🔹 Preclinical Drug Development
All applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, or protected veteran status.
👉 Interested? Apply today!
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